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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac danger components utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, probably secondary to high-dose testosterone. The patient underwent profitable percutaneous intervention of the right coronary artery. Physicians and patients should concentrate on the clinical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996).
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Moreover, a part of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity. However, testosterone in physiologic doses might even be beneficial in patients with angina , have higher ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood move in males with established coronary artery disease . Therefore, an interaction of endogenous factors of the patient’s threat profile as properly as the testosterone dosing could also be issues of whether adverse occasions occur.
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Rhoden EL, Morgentaler A. Risks of testosterone-replacement remedy and proposals for monitoring. Testosterone alternative in hypogonadal men with angina improves ischaemic threshold and quality of life. Ajayi AAL, Mathur R, Halushka PV. Testosterone enhance human platelet thromboxane A2 receptor density and aggregation responses.
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